Our Innovation services are listed below. If you would like more information, please download and complete our request form.
 

Experimental Consultation & Bioinformatics

  • Advice and information on starting a microbiome project or on how to use our technological resources and those of our affiliated centers and research groups to develop projects that test biological function
  • Review sequencing data and discuss microbes of interest
  • Bioinformatic analysis of your data sets (coming soon)

Clinical Microbiome Service

  • Microbiome cultivation of targeted species from stool or other samples
  • Inflammatory bowel disease microbiome biorepository of well-defined studies or patient groups that will allow longitudinal sampling and analysis of the same micorbiome species over the course of treatment, progression, or clinical trial
     

BACTRON900

Shel Lab's BACTRON900 can house up to 900 plates

Equipment & Technologies
Shel Lab Bactron900 anaerobic chamber, Bruker matrix-assisted laser desorption ionization time of flight (MALDI-TOF) mass spectrometry


Microbiome & Host Imaging

  • Isolate single cells, mucus layers or anatomical structures from histological samples 
  • Determine spatial relationship between specific species of microbiome and host tissue  
  • Specific probes for microbial species
     

Leica LMD7000

Specimen collection by gravity – contact-free and contamination-free. Laser Microdissection (LMD) makes it possible to distinguish between relevant and non-relevant cells or tissues. It enables the researcher to obtain homogeneous, ultra-pure samples from heterogeneous starting material.

Equipment & Technologies
Leica laser capture microdissection microscope (LMD7000), Leica fluorescent microscope


Host-Microbiome Interactions

  • In vivo models: disease models
  • In vitro models: human and murine intestinal organoids, epithelial cells lines
  • Molecular and cellular immune assays 
  • Screen potential therapeutics in any of these models
     

Equipment & Technologies
Human intestinal organoids for drug and bacterial screening, LICOR Odyssey Fc Imaging system, gnotobiotic facility, affiliated resource through the Gnotobiotic Animal Core (GNAC), Luminex multiplex cytokine assays

 

Intestinal Organoids

With just a tiny tissue sample, we have the ability to actually grow three-dimensional intestinal organoids or “mini-guts” as they are known here in the lab, in less than a week. These mini-guts retain key features of the intestinal epithelium, including all of the major epithelial cell types, making them an ideal tool to help us isolate and understand the different mechanisms at play in IBD versus healthy intestinal tissue.

 

For more information, please download and complete the following form.